Endocrine Abstracts

Introduction: Nonislet cell tumour hypoglycemia (NICTH) is a rare complication of malignancy. The most common cause is overproduction of IGF2, which activates insulin receptors, resulting in hypoinsulinemic hypoglycemia. When a solitary fibrous tumor is responsible, it is called Doege-Potter syndrome.Case 1: 58-year-old woman, with a history of gastrointestinal stromal tumor and pleural solitary fibrous tumor with pulmonary and lymph node metastases. She...

Introduction: Bilateral adrenal masses may appear in the context of metastatic disease, adrenal congenital hyperplasia, primary tumors or infections, among others. Primary adrenal lymphoma is rare, accounting for approximately 1% of cases of non-Hodgkin lymphoma. Clinical case: 47-year-old woman, with a history of erythema nodosum and left hemithyroidectomy in the context of benign nodular disease. She presented with persistent fever and tiredne...

Introduction: Differentiated thyroid cancer (DTC) is rare in the paediatric population when compared to adults. Paediatric patients often present with advanced disease at diagnosis, characterized by multifocal disease, heightened lymph node involvement, and distant metastasis. Additionally, they face a higher risk of post-operative complications in comparison to adults. Despite that, paediatric DTC exhibits an excellent prognosis.Methods: A retrospective...

Introduction: Adrenocortical carcinoma is a rare type of cancer that usually has a dismal prognosis. The concurrent hormonal excess of some of these tumours can have an additional negative impact on patients´ morbidity and mortality.Clinical Case: We present the case of a 57-year-old woman diagnosed with stage IV adrenocortical carcinoma, with liver and bone metastasis, and associated ACTH-independent Cushing syndrome and hyperandrogenism. The patie...

Introduction: Pancreatic neuroendocrine tumors (PNETs) originate from neuroendocrine islet cells and can therefore secrete several neuropeptides. Multiple and secondary hormone secretion have been described in a minority of cases, mostly with advanced disease, and it has been hypothesized that this complex secretion pattern can serve as a marker for tumor behavior.Case report: Male patient, 69 years old, diagnosed with a glucagonoma with pulmonary and he...

Introduction: Cancer treatment including oophorectomy, radiotherapy and chemotherapy with gonadotoxic agents may induce premature ovarian failure. Early diagnosis and treatment of ovarian failure avoids cardiovascular disorders, osteoporosis and compromised sexual health due to estrogen deficiency and also ensures growth and pubertal development in children.Aim: Raise awareness for early assessment and management of premature ovarian failure after cancer...

Introduction: Hyperthyroidism is an endocrine condition with multiple causes. Paraneoplastic hyperthyroidism due to marked overproduction of human chorionic gonadotropin (hCG) by choriocarcinoma is a rare diagnosis, which results from the homology of the alpha subunit of hCG to TSH.Clinical case: A 33-year-old man, with a history of cryptorchidism and orchidopexy in infancy and a euthyroid thyroid nodule, presented with nausea, constipation, and abdomina...

Background: Bariatric surgery leads to weight loss and to cardiometabolic risk improvement. Although prediabetes remission after bariatric surgery is biologically plausible, data on this topic is scarce.Aim: We aimed to access pre-diabetes remission rate and clinical predictors of remission in a 4 year follow up period.Methods: Observational longitudinal study including patients with morbid obesity and prediabetes submitted to bari...